BDBM60917 9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;methanesulfonic acid::9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;mesylic acid::9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;methanesulfonic acid::FENOLDOPAM::FENOLDOPAM MESYLATE::MLS001401388::SMR000469190::cid_49659

SMILES Oc1ccc(cc1)C1CNCCc2c(Cl)c(O)c(O)cc12

InChI Key InChIKey=TVURRHSHRRELCG-UHFFFAOYSA-N

Data  20 KI  9 IC50  5 Kd  5 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 60917   

LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390More data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataKi:  17nMMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataKi:  28nMMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataKi:  40nMAssay Description:Affinity towards Dopamine receptor D1More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataKi:  1.82E+3nMMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataEC50:  2.80nMAssay Description:Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation aft...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataKd:  28nMAssay Description:Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsMore data for this Ligand-Target Pair
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataEC50:  57nMAssay Description:Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataEC50:  2.70E+3nMMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Affinity DataIC50:  8.04E+3nMMore data for this Ligand-Target Pair